Aim of this research project is to clarify the contribution of Sprouty proteins in

1. deregulation of cell proliferation
2. modulating morphology, mobility and invasion of the cells
3. immortalisation of the cells
4. desensitising the cellular response to different positive and negative signals.

The results will enable us to assess whether and to which extent the Sprouty proteins can represent a helpful tool in developing therapeutics against specific tumour types.

Sprouty2, but not Sprouty1 expression is down regulated in NSCLC. A RT-PCR of Sprouty1 and Sprouty2 using total RNA from tumour (T) and corresponding normal lung (N) tissues. B, C, D, E Immunohistochemistry from lung tissue section including NSCLC and adjacent normal bronchial epithelium using Sprouty2 antibody.

This project is executed by: Rosana Kral, Angelina Doriguzzi

In cooperation with: U. Setinek, D. Krenbek (Otto Wagner Spital, Wien)

Financed by: Jubiläumsfonds der Österreichische Nationalbank, Herzfelder’sche Familienstiftung

Research Focus: Development of Experimental Cancer Therapies