Dietmar Herndler-Brandstetter, Mag.pharm. PhD
Group Leader
E-Mail: dietmar.herndler-brandstetter [at] meduniwien [dot] ac [dot] at
Phone: +43 (0)1 40160 - 57577
Fax: +43 (0)1 40160 - 957526
Research Focus
1. Humanized mouse models for translational cancer research and immunotherapy
We developed novel humanized mice (immunodeficient mice reconstituted with a human immune system), which represent highly innovative models for translational research and personalized medicine, as they allow in vivo modeling and therapy of human diseases, in particular cancer.
2. Long noncoding RNA regulation of adaptive immunity
Long noncoding RNAs (lncRNAs) play a key role in regulating tumor growth and immune cell responses. By using deep RNA-seq we identified novel lncRNAs regulated during adaptive immunity. By using CRISPR/Cas9-mediated genome engineering, we generated knockout mice to understand how lncRNAs regulate immune cell development and adaptive immunity.
3. Stromal regulation of immune cell development
Stromal cells maintain hematopoietic stem cells (HSC) and provide lineage-instructive differentiation signals for lymphoid progenitors. We have developed reporter and conditional knockout mice to investigate the role of distinct subsets of stromal cells for immune cell development and the regulation of immune cell responses.
Funding
FWF Stand Alone (P 33340)
FWF doc.funds (DOC59-B33)
OEAW DOC PhD Fellowship
Fellinger Cancer Research Foundation
WWTF Life Sciences 2020 Precision Medicine (LS20-042)
Group Members
Selected Publications
KLRG1+ Effector CD8+ T Cells Lose KLRG1, Differentiate into All Memory T Cell Lineages, and Convey Enhanced Protective Immunity
Herndler-Brandstetter D*, Ishigame H*, Shinnakasu R, Plajer V, Stecher C, Zhao J, Lietzenmayer M, Kroehling L, Takumi A, Kometani K, Inoue T, Kluger Y, Kaech SM, Kurosaki T, Okada T, Flavell RA.;
Immunity. 2018 Apr 17;48(4):716-729.e8. doi: 10.1016/j.immuni.2018.03.015. Epub 2018 Apr 3. (* joint first authors)
Anti-SIRPa antibody immunotherapy enhances neutrophil and macrophage antitumor activity.
Ring NG*, Herndler-Brandstetter D*, Weiskopf K*, Shan L, Volkmer JP, George BM, Lietzenmayer M, McKenna KM, Naik TJ, McCarty A, Zheng Y, Ring AM, Flavell RA, Weissman IL.;
Proc Natl Acad Sci U S A. 2017 Dec 5;114(49):E10578-E10585. doi: 10.1073/pnas.1710877114. Epub 2017 Nov 20. (* joint first authors)
Humanized mouse model supports development, function, and tissue residency of human natural killer cells.
Herndler-Brandstetter D*, Shan L*, Yao Y, Stecher C, Plajer V, Lietzenmayer M, Strowig T, de Zoete MR, Palm NW, Chen J, Blish CA, Frleta D, Gurer C, Macdonald LE, Murphy AJ, Yancopoulos GD, Montgomery RR, Flavell RA.;
Proc Natl Acad Sci U S A. 2017 Nov 7;114(45):E9626-E9634. doi: 10.1073/pnas.1705301114. Epub 2017 Oct 25. (* joint first authors)
Hematopoietic stem cell niches produce lineage-instructive signals to control multipotent progenitor differentiation.
Cordeiro Gomes A*, Hara T*, Lim VY*, Herndler-Brandstetter D, Nevius E, Sugiyama T, Tani-Ichi S, Schlenner S, Richie E, Rodewald HR, Flavell RA, Nagasawa T, Ikuta K, Pereira JP.;
Immunity. 2016 Dec 20;45(6):1219-1231. doi: 10.1016/j.immuni.2016.11.004. Epub 2016 Nov 29. (* joint first authors)
CD58/CD2 is the primary costimulatory pathway in human CD28-CD8+ T cells.
Leitner J, Herndler-Brandstetter D, Zlabinger GJ, Grubeck-Loebenstein B, Steinberger P.;
J Immunol. 2015 Jul 15;195(2):477-87. doi: 10.4049/jimmunol.1401917. Epub 2015 Jun 3.
How aging affects T lymphocyte-mediated immunity.
Herndler-Brandstetter D.;
Front Immunol. 2013 Sep 24;4:296. doi: 10.3389/fimmu.2013.00296. eCollection 2013. (Editorial)