Brigitte Marian, Group Leader
E-mail: brigitte.marian@meduniwien.ac.at
Phone: +43 (0)1 40160 - 57522
Fax: +43 (0)1 40160 - 957500
Research Focus:
Colorectal cancer (CRC) develops from normal mucosa cells by the step-by-step accumulation of mutations and a progressive dys-regulation of growth. This affects several signalling pathways – including the epidermal growth factor receptor, the transforming growth factor receptor ß, insulin-like growth factors and fibroblast growth factors (FGFs) and their receptors (FGFRs). We have established in vitro models for colon adenomas and carcinomas which we use to analyse tumor specific signalling pathways and to investigate the efficacy of therapeutic compounds.
Group Members
Selected Publications:
Fibroblast growth factor receptor 4 induced resistance to radiation therapy in colorectal cancer. Ahmed MA, Selzer E, Dörr W, Jomrich G, Harpain F, Silberhumer GR, Müllauer L, Holzmann K, Grasl-Kraupp B, Grusch M, Berger W, Marian B. Oncotarget. 2016 Sep 17. doi: 10.18632/oncotarget.12099. [Epub ahead of print]
Autocrine fibroblast growth factor 18 signaling mediates Wnt-dependent stimulation of CD44-positive human colorectal adenoma cells. Koneczny I, Schulenburg A, Hudec X, Knöfler M, Holzmann K, Piazza G, Reynolds R, Valent P, Marian B. Mol Carcinog. 2015 Sep;54(9):789-99
Differential effects of polymorphic alleles of FGF receptor 4 on colon cancer growth and metastasis. Heinzle C, Gsur A, Hunjadi M, Erdem Z, Gauglhofer C, Stättner S, Karner J, Klimpfinger M, Wrba F, Reti A, Hegedus B, Baierl A, Grasl-Kraupp B, Holzmann K, Grusch M, Berger W, Marian B. Cancer Res. 2012 Nov 15;72(22):5767-77
Fibroblast growth factor receptor 3-IIIc mediates colorectal cancer growth and migration. Sonvilla G, Allerstorfer S, Heinzle C, Stättner S, Karner J, Klimpfinger M, Wrba F, Fischer H, Gauglhofer C, Spiegl-Kreinecker S, Grasl-Kraupp B, Holzmann K, Grusch M, Berger W, Marian B Br J Cancer. 2010 Mar 30;102(7):1145-56
FGF18 in colorectal tumour cells: autocrine and paracrine effects. Sonvilla G, Allerstorfer S, Stättner S, Karner J, Klimpfinger M, Fischer H, Grasl-Kraupp B, Holzmann K, Berger W, Wrba F, Marian B, Grusch M. Carcinogenesis. 2008 Jan;29(1):15-24