Genomic Signatures and Novel Treatment Strategies of Malignant Pleural Mesothelioma (MPM) and Osteosarcoma (OS)

Aim of this project is to investigate on a genome-wide basis the molecular alterations of MPM/OS by using modern array CGH technology on tumor specimen, primo-cell cultures and stable MPM/OS cell lines. In parallel the anti-cancer activities in vitro and in vivo of several new (targeted) anticancer drugs (mTOR-inhibitors, tyrosine kinase inhibitors etc.) are analysed against panels of cell cultures and cell lines established from patients with MPM/OS. Mechanisms underlying malignant growth ant treatment response are investigated.

Array CGH analysis revealing massive amplification of a chromosomal region on chromosome 1q comprising amongst other the SOX13 gene.


Christine Pirker, Post-Doc
Mir Alireza Hoda, Phd
Bahil Ghanim, Phd
Lisa Mayer, Master Student
Thomas Schöfl, Master Student

Cooperation:
W. Klepetko, B. Döme, B. Hegedus (AKH, Department of Thoracic Surgery)
R. Pirker (AKH, KIMI, Department of Oncology)
M. Filipits (Institute of Cancer Research)
B. Kubista, R.Windhager (AKH, Department of Orthopaedics)