Bettina Grasl-Kraupp, Ao.Univ.-Prof. Dr.
Gruppenleiterin
EUROPEAN Registered Toxicologist
E-Mail: bettina.grasl-kraupp [at] meduniwien [dot] ac [dot] at
Phone: +43 (0)1 40160 - 57564
Fax: +43 (0)1 40160 - 957616
Research Focus
Hepatocellular carcinoma is one of the most common fatal cancers worldwide with an increasing incidence in many countries, including Austria. This malignancy almost always develops in a chronically inflamed liver. It is assumed that unresolved inflammation evokes cell turnover in an effort to restore tissue homeostasis. In this process, deregulated cytokine production and aberrant cytokine signaling may lead to altered cell growth, differentiation, and apoptosis. The result may be formation and selection of premalignant hepatocytes, which increasingly lose normal growth control and may give rise to cancer.
Videos
Selected Publications
Proinflammatory mesenchymal effects of the non-genotoxic hepatocarcinogen phenobarbital: a novel mechanism of antiapoptosis and tumor promotion.
Riegler T, Nejabat M, Eichner J, Stiebellehner M, Subosits S, Bilban M, Zell A, Huber WW, Schulte-Hermann R, Grasl-Kraupp B.
Carcinogenesis. 2015 Dec;36(12):1521-30. doi: 10.1093/carcin/bgv135.
Fibroblast growth factor receptor 3 isoforms: Novel therapeutic targets for hepatocellular carcinoma?
Paur J, Nika L, Maier C, Moscu-Gregor A, Kostka J, Huber D, Mohr T, Heffeter P, Schrottmaier WC, Kappel S, Kandioler D, Holzmann K, Marian B, Berger W, Grusch M, Grasl-Kraupp B.;
Hepatology. 2015 Dec;62(6):1767-78. doi: 10.1002/hep.28023.
Food-derived peroxidized fatty acids may trigger hepatic inflammation: a novel hypothesis to explain steatohepatitis.
Böhm T, Berger H, Nejabat M, Riegler T, Kellner F, Kuttke M, Sagmeister S, Bazanella M, Stolze K, Daryabeigi A, Bintner N, Murkovic M, Wagner KH, Schulte-Hermann R, Rohr-Udilova N, Huber W, Grasl-Kraupp B.;
J Hepatol. 2013 Sep;59(3):563-70. doi: 10.1016/j.jhep.2013.04.025.
Up-regulation of the fibroblast growth factor 8 subfamily in human hepatocellular carcinoma for cell survival and neoangiogenesis.
Gauglhofer C, Sagmeister S, Schrottmaier W, Fischer C, Rodgarkia-Dara C, Mohr T, Stättner S, Bichler C, Kandioler D, Wrba F, Schulte-Hermann R, Holzmann K, Grusch M, Marian B, Berger W, Grasl-Kraupp B.;
Hepatology. 2011 Mar;53(3):854-64. doi: 10.1002/hep.24099
NORE1B is a putative tumor suppressor in hepatocarcinogenesis and may act via RASSF1A.
Macheiner D, Gauglhofer C, Rodgarkia-Dara C, Grusch M, Brachner A, Bichler C, Kandioler D, Sutterlüty H, Mikulits W, Schulte-Hermann R, Grasl-Kraupp B.;
Cancer Res. 2009 Jan 1;69(1):235-42. doi: 10.1158/0008-5472.CAN-08-2144.