Dissecting tumor-immune interactions in organ-specific metastasis using single-cell and spatial omics approaches
What we do:
Metastasis is the leading cause of cancer related deaths. Specific cancers have a prevalence to metastasize to specific organs. The underlying mechanisms for this organotropism are poorly understood. In this project you will investigate how tumor and metastatic cells and their immune-microenvironment are different in different host organs and how malignant cells remodel distant tissue niches. We are focusing on finding ways to empower the immune system to combat metastasis using cutting-edge single-cell and spatial omics technologies. We use clinically highly relevant disease models of metastasis and patient samples to investigate the complex interplays of tumor and immune cells in metastasis. The use of modern omics technologies makes it possible to discover new tumor immune cell interactions in metastasis that have not been described before. By studying these interactions between metastatic cancer cells and immune cells, we hope to uncover new insights that could lead to improved treatments for cancer patients.
What we offer:
Fully funded PhD position! Our interdisciplinary approach combines different expertise to tackle the complex interplay of tumor and immune cells in metastasis including experimental and computational biology, as well as translational research. As a member of our dynamic team, you will receive training in both experimental and computational biology that are equally important skill sets for modern cancer researchers. You will be trained to generate and analyze single-cell and spatial omics data using the latest technologies, learn how to generate scientific hypothesis and to validate your hypothesis in appropriate advanced in vitro organoid and in vivo metastasis model systems. You will have the opportunity to present your work at conferences and collaborate with researchers from around the world, helping you grow professionally and make valuable connections in the field.
As part of the unique SHIELD PhD program, you will have access to coordinated courses and workshops and a network of experts in immunology and cancer, providing even more opportunities for learning and collaboration.
What we are looking for:
- Master in Biochemistry, Molecular biology, Immunology, Computational Biology or equivalent.
- Experience in computational biology and/or immunology are desirable
- Excitement to work both computationally (analyzing single-omics and spatial omics data) and experimentally (e.g. working with mouse models)
- Strong team spirit and high motivation to push the boundaries of metastatic research to improve patient outcomes.
Keywords: AI/ML, Animal research, Human research, Wet lab, Computer lab, Bioinformatics, Cancer, Immunology
Join our team and do your PhD in vibrant Vienna - one of the most livable cities worldwide!
More info here : winklerlab.org or email juliane.winkler@meduniwien.ac.at.
