Robert Eferl, Assoc. Prof. Priv.-Doz. Mag. Dr.
Gruppenleiter
E-Mail: robert.eferl [at] meduniwien [dot] ac [dot] at
Phone: +43 (0)1 40160 - 57571
Fax: +43 (0)1 40160 - 957510
Research Focus
We are working on two topics:
1) We identify cooperative signaling pathways in cancer formation using novel mouse models.
2) We focus on functions of STAT transcription factors in inflammatory liver damage and cancer types that are associated with inflammation (also at: www.jak-stat.at)
Videos
Selected Publications
STAT1 is a sex-specific tumor suppressor in colitis-associated colorectal cancer.
Crnčec I, Modak M, Gordziel C, Svinka J, Scharf I, Moritsch S, Pathria P, Schlederer M, Kenner L, Timelthaler G, Müller M, Strobl B, Casanova E, Bayer E, Mohr T, Stöckl J, Friedrich K, Eferl R.
Mol Oncol. 2018 Apr;12(4):514-528. doi: 10.1002/1878-0261.12178
Epidermal growth factor signaling protects from cholestatic liver injury and fibrosis.
Svinka J, Pflügler S, Mair M, Marschall HU, Hengstler JG, Stiedl P, Poli V, Casanova E, Timelthaler G, Sibilia M, Eferl R.
J Mol Med (Berl). 2017 Jan;95(1):109-117. doi: 10.1007/s00109-016-1462-8.
Myeloid STAT3 promotes formation of colitis-associated colorectal cancer in mice.
Pathria P, Gotthardt D, Prchal-Murphy M, Putz EM, Holcmann M, Schlederer M, Grabner B, Crncec I, Svinka J, Musteanu M, Hoffmann T, Filipits M, Berger W, Poli V, Kenner L, Bilban M, Casanova E, Müller M, Strobl B, Bayer E, Mohr T, Sexl V, Eferl R.
Oncoimmunology. 2015 Jan 22;4(4):e998529. eCollection 2015
A mouse model to identify cooperating signaling pathways in cancer.
Musteanu M, Blaas L, Zenz R, Svinka J, Hoffmann T, Grabner B, Schramek D, Kantner HP, Müller M, Kolbe T, Rülicke T, Moriggl R, Kenner L, Stoiber D, Penninger JM, Popper H, Casanova E, Eferl R.
Nat Methods. 2012 Sep;9(9):897-900. doi: 10.1038/nmeth.2130
STAT3 protects from liver injury and fibrosis in a mouse model of sclerosing cholangitis.
Mair M, Zollner G, Schneller D, Musteanu M, Fickert P, Gumhold J, Schuster C, Fuchsbichler A, Bilban M, Tauber S, Esterbauer H, Kenner L, Poli V, Blaas L, Kornfeld JW, Casanova E, Mikulits W, Trauner M, Eferl R.
Gastroenterology. 2010 Jun;138(7):2499-508. doi: 10.1053/j.gastro.2010.02.049.