Gsur Labor

Ausgewählte Publikationen

Genome-wide association study and Mendelian randomization analyses provide insights into the causes of early-onset colorectal cancer
Laskar RS, Qu C, Huyghe JR, Harrison T, Hayes RB, Cao Y, Campbell PT, Steinfelder R, Talukdar FR, Brenner H, Ogino S, Brendt S, Bishop DT, Buchanan DD, Chan AT, Cotterchio M, Gruber SB, Gsur A, van Guelpen B, Jenkins MA, Keku TO, Lynch BM, Le Marchand L, Martin RM, McCarthy K, Moreno V, Pearlman R, Song M, Tsilidis KK, Vodička P, Woods MO, Wu K, Hsu L, Gunter MJ, Peters U, Murphy N; Colorectal Transdisciplinary (CORECT) Study, the Colon Cancer Family Registry (CCFR), Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO).
Ann Oncol. 2024 Feb 24:S0923-7534(24)00058-9. doi: 10.1016/j.annonc.2024.02.008. Online ahead of print.PMID: 38408508 

Using fecal immmunochemical cartridges for gut microbiome analysis within a colorectal cancer screening program
Brezina S, Borkovec M, Baierl A, Bastian F, Futschik A, Gasche N, Gruenberger T, Hallas M, Jannsen C, Leeb G, Lutz R, Sladek B, Gsur A.
Gut Microbes. 2023 Jan-Dec;15(1):2176119. doi: 10.1080/19490976.2023.2176119.PMID: 36794815 

Combining Asian and European genome-wide association studies of colorectal cancer improves risk prediction across racial and ethnic populations
Thomas M, Su YR, Rosenthal EA, Sakoda LC, Schmit SL, Timofeeva MN, Chen Z, Fernandez-Rozadilla C, Law PJ, Murphy N, Carreras-Torres R, Diez-Obrero V, van Duijnhoven FJB, Jiang S, Shin A, Wolk A, Phipps AI, Burnett-Hartman A, Gsur A, Chan AT, Zauber AG, Wu AH, Lindblom A, Um CY, Tangen CM, Gignoux C, Newton C, Haiman CA, Qu C, Bishop DT, Buchanan DD, Crosslin DR, Conti DV, Kim DH, Hauser E, White E, Siegel E, Schumacher FR, Rennert G, Giles GG, Hampel H, Brenner H, Oze I, Oh JH, Lee JK, Schneider JL, Chang-Claude J, Kim J, Huyghe JR, Zheng J, Hampe J, Greenson J, Hopper JL, Palmer JR, Visvanathan K, Matsuo K, Matsuda K, Jung KJ, Li L, Le Marchand L, Vodickova L, Bujanda L, Gunter MJ, Matejcic M, Jenkins MA, Slattery ML, D'Amato M, Wang M, Hoffmeister M, Woods MO, Kim M, Song M, Iwasaki M, Du M, Udaltsova N, Sawada N, Vodicka P, Campbell PT, Newcomb PA, Cai Q, Pearlman R, Pai RK, Schoen RE, Steinfelder RS, Haile RW, Vandenputtelaar R, Prentice RL, Küry S, Castellví-Bel S, Tsugane S, Berndt SI, Lee SC, Brezina S, Weinstein SJ, Chanock SJ, Jee SH, Kweon SS, Vadaparampil S, Harrison TA, Yamaji T, Keku TO, Vymetalkova V, Arndt V, Jia WH, Shu XO, Lin Y, Ahn YO, Stadler ZK, Van Gue…See abstract for full author list ➔
Nat Commun. 2023 Oct 2;14(1):6147. doi: 10.1038/s41467-023-41819-0.PMID: 37783704 

Novel insights into genetic susceptibility for colorectal cancer from transcriptome-wide association and functional investigation
Chen Z, Song W, Shu XO, Wen W, Devall M, Dampier C, Moratalla-Navarro F, Cai Q, Long J, Van Kaer L, Wu L, Huyghe JR, Thomas M, Hsu L, Woods MO, Albanes D, Buchanan DD, Gsur A, Hoffmeister M, Vodicka P, Wolk A, Marchand LL, Wu AH, Phipps AI, Moreno V, Ulrike P, Zheng W, Casey G, Guo X.
J Natl Cancer Inst. 2024 Jan 10;116(1):127-137. doi: 10.1093/jnci/djad178.PMID: 37632791

A Genetic Locus within the FMN1/GREM1 Gene Region Interacts with Body Mass Index in Colorectal Cancer Risk
Aglago EK, Kim A, Lin Y, Qu C, Evangelou M, Ren Y, Morrison J, Albanes D, Arndt V, Barry EL, Baurley JW, Berndt SI, Bien SA, Bishop DT, Bouras E, Brenner H, Buchanan DD, Budiarto A, Carreras-Torres R, Casey G, Cenggoro TW, Chan AT, Chang-Claude J, Chen X, Conti DV, Devall M, Diez-Obrero V, Dimou N, Drew D, Figueiredo JC, Gallinger S, Giles GG, Gruber SB, Gsur A, Gunter MJ, Hampel H, Harlid S, Hidaka A, Harrison TA, Hoffmeister M, Huyghe JR, Jenkins MA, Jordahl K, Joshi AD, Kawaguchi ES, Keku TO, Kundaje A, Larsson SC, Marchand LL, Lewinger JP, Li L, Lynch BM, Mahesworo B, Mandic M, Obón-Santacana M, Moreno V, Murphy N, Nan H, Nassir R, Newcomb PA, Ogino S, Ose J, Pai RK, Palmer JR, Papadimitriou N, Pardamean B, Peoples AR, Platz EA, Potter JD, Prentice RL, Rennert G, Ruiz-Narvaez E, Sakoda LC, Scacheri PC, Schmit SL, Schoen RE, Shcherbina A, Slattery ML, Stern MC, Su YR, Tangen CM, Thibodeau SN, Thomas DC, Tian Y, Ulrich CM, van Duijnhoven FJ, Van Guelpen B, Visvanathan K, Vodicka P, Wang J, White E, Wolk A, Woods MO, Wu AH, Zemlianskaia N, Hsu L, Gauderman WJ, Peters U, Tsilidis KK, Campbell PT.
Cancer Res. 2023 Aug 1;83(15):2572-2583. doi: 10.1158/0008-5472.CAN-22-3713.PMID: 37249599 

Identification of tumor tissue-derived DNA methylation biomarkers for the detection and therapy response evaluation of metastatic castration resistant prostate cancer in liquid biopsies
Dillinger, T., R. Sheibani-Tezerji, W. Pulverer, I. Stelzer, M.R. Hassler, J. Scheibelreiter, C.U. Pérez Malla, M. Kuroll, S. Domazet, E. Redl, S. Ely, S. Brezina, A. Tiefenbacher, K. Rebhan, N. Hübner, B. Grubmüller, M. Mitterhauser, M. Hacker, A. Weinhaeusel, J. Simon, M. Zeitlinger, A. Gsur, G. Kramer, S.F. Shariat, L. Kenner, G. Egger,
Mol Cancer. 2022. 21(1): p. 7. doi.10.1186/s12943-021-01445-0

Colorectal Cancer Study of Austria (CORSA): A Population-Based Multicenter Study
Gsur A, Baierl A, Brezina S
Biology. 2021 Jul 28;10(8):722. doi: 10.3390/biology10080722.

Genome-wide analysis of 944 133 individuals provides insights into the etiology of haemorrhoidal disease
Zheng, T., D. Ellinghaus, S. Juzenas, F. Cossais, G. Burmeister, G. Mayr, I.F. Jørgensen, M. Teder-Laving, A.H. Skogholt, S. Chen, P.R. Strege, G. Ito, K. Banasik, T. Becker, F. Bokelmann, S. Brunak, S. Buch, H. Clausnitzer, C. Datz, F. Degenhardt, M. Doniec, C. Erikstrup, T. Esko, M. Forster, N. Frey, L.G. Fritsche, M.E. Gabrielsen, T. Gräßle, A. Gsur, J. Gross, J. Hampe, A. Hendricks, S. Hinz, K. Hveem, J. Jongen, R. Junker, T.H. Karlsen, G. Hemmrich-Stanisak, W. Kruis, J. Kupcinskas, T. Laubert, P.C. Rosenstiel, C. Röcken, M. Laudes, F.H. Leendertz, W. Lieb, V. Limperger, N. Margetis, K. Mätz-Rensing, C.G. Németh, E. Ness-Jensen, U. Nowak-Göttl, A. Pandit, O.B. Pedersen, H.G. Peleikis, K. Peuker, C.L. Rodriguez, M.C. Rühlemann, B. Schniewind, M. Schulzky, J. Skieceviciene, J. Tepel, L. Thomas, F. Uellendahl-Werth, H. Ullum, I. Vogel, H. Volzke, L. von Fersen, W. von Schönfels, B. Vanderwerff, J. Wilking, M. Wittig, S. Zeissig, M. Zobel, M. Zawistowski, V. Vacic, O. Sazonova, E.S. Noblin, G. Farrugia, A. Beyder, T. Wedel, V. Kahlke, C. Schafmayer, M. D'Amato, A. Franke
Gut. 2021. doi.10.1136/gutjnl-2020-323868

Untargeted Metabolomics Reveals Major Differences in the Plasma Metabolome between Colorectal Cancer and Colorectal Adenomas.
Gumpenberger T, Brezina S, Keski-Rahkonen P, Baierl A, Robinot N, Leeb G, Habermann N, Kok DEG, Scalbert A, Ueland PM, Ulrich CM, Gsur A.
Metabolites. 2021 Feb 19;11(2):119.

Genetic architectures of proximal and distal colorectal cancer are partly distinct.
Huyghe JR, Harrison TA, Bien SA, Hampel H, Figueiredo JC, Schmit SL, Conti DV, Chen S, Qu C, Lin Y, Barfield R, Baron JA, Cross AJ, Diergaarde B, Duggan D, Harlid S, Imaz L, Kang HM, Levine DM, Perduca V, Perez-Cornago A, Sakoda LC, Schumacher FR, Slattery ML, Toland AE, van Duijnhoven FJB, Van Guelpen B, Agudo A, Albanes D, Alonso MH, Anderson K, Arnau-Collell C, Arndt V, Banbury BL, Bassik MC, Berndt SI, Bézieau S, Bishop DT, Boehm J, Boeing H, Boutron-Ruault MC, Brenner H, Brezina S, Buch S, Buchanan DD, Burnett-Hartman A, Caan BJ, Campbell PT, Carr PR, Castells A, Castellví-Bel S, Chan AT, Chang-Claude J, Chanock SJ, Curtis KR, de la Chapelle A, Easton DF, English DR, Feskens EJM, Gala M, Gallinger SJ, Gauderman WJ, Giles GG, Goodman PJ, Grady WM, Grove JS, Gsur A, Gunter MJ, Haile RW, Hampe J, Hoffmeister M, Hopper JL, Hsu WL, Huang WY, Hudson TJ, Jenab M, Jenkins MA, Joshi AD, Keku TO, Kooperberg C, Kühn T, Küry S, Le Marchand L, Lejbkowicz F, Li CI, Li L, Lieb W, Lindblom A, Lindor NM, Männistö S, Markowitz SD, Milne RL, Moreno L, Murphy N, Nassir R, Offit K, Ogino S, Panico S, Parfrey PS, Pearlman R, Pharoah PDP, Phipps AI, Platz EA, Potter JD, Prentice RL, Qi L, Raskin L, Rennert G, Rennert HS, Riboli E, Schafmayer C, Schoen RE, Seminara D, Song M, Su YR, Tangen CM, Thibodeau SN, Thomas DC, Trichopoulou A, Ulrich CM, Visvanathan K, Vodicka P, Vodickova L, Vymetalkova V, Weigl K, Weinstein SJ, White E, Wolk A, Woods MO, Wu AH, Abecasis GR, Nickerson DA, Scacheri PC, Kundaje A, Casey G, Gruber SB, Hsu L, Moreno V, Hayes RB, Newcomb PA, Peters U.
Gut. 2021 Feb 25:gutjnl-2020-321534.

Plasma metabolites associated with colorectal cancer: A discovery-replication strategy.
Geijsen JMRA*, Brezina S*, Keski-Rahkonen P, Baierl A, Bachleitner-Hofmann T, Bergmann MM, Boehm J, Brenner H, Chang-Claude J, Duijnhoven van JBF, Gigic B, Gumpenberger T, Hofer P, Hoffmeister M, Holowatyj NA, Karner-Hanusch J, Kok ED, Leeb G, Ulvik A, Robinot N, Ose J, Stift A, Schrotz-King P, Ulrich BA, Ueland PM, Kampman E, Scalbert A, Habermann N*, Gsur A*, Ulrich MC*.
Int. J. Cancer. 2019 Jan 21. doi: 10.1002/ijc.32146.

Genome-wide association analysis of diverticular disease points towards neuromuscular, connective tissue and epithelial pathomechanisms.
Schafmayer C*, Harrison JW*, Buch S*, Hofer P, Brezina S, Wedel T*, Datz C*, Gsur A*, Weedon MN*, Hampe J*.
Gut. 2019 Jan 19. doi: 10.1136/gutjnl-2018-317619.

Discovery of common and rare genetic risk variants for colorectal cancer
Huyghe JR*, Bien SA*, Harrison TA*, Brezina S, Hofer P, Gsur A, Nickerson DA*, Gruber SB*, Hsu L*, Peters U*.
Nature Genetics. 2019 Jan;51(1):76-87.

*contributed equally

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