Research from the laboratory to the patient and vice versa
Around 20 innovative research projects are initiated at the Center for Cancer Research every year. Due to the affiliation of the center to the Medical University of Vienna and the proximity to the AKH Wien (Vienna General Hospital), basic research and clinic can work together very closely and the research results flow directly into diagnosis and therapy.
Our vision: Cancer is a conquerable and curable disease!
Systemic IFN-I combined with topical TLR7/8 agonists promotes distant tumor suppression by c-Jun-dependent IL-12 expression in dendritic cells
Martina Sanlorenzo #, Philipp Novoszel #, Igor Vujic, Tommaso Gastaldi, Martina Hammer, Ourania Fari, Cristiano De Sa Fernandes, Alina D Landau, Bilge V Göcen-Oguz 1 , Martin Holcmann, Babak Monshi, Klemens Rappersberger, Agnes Csiszar, Maria Sibilia
#Contributed equally.
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#Contributed equally.
Alternative lengthening of telomere-based immortalization renders H3G34R -mutant diffuse hemispheric glioma hypersensitive to PARP inhibitor combination regimens
Anna Laemmerer, Christian Lehmann, Lisa Mayr, Katharina Bruckner, Lisa Gabler, Daniel Senfter, Philipp Meyer, Theresa Balber, Christine Pirker, Carola N Jaunecker, Dominik Kirchhofer, Petra Vician, Michelle Griesser, Sabine Spiegl-Kreinecker, Maria T Schmook, Tatjana Traub-Weidinger, Peter Kuess, Franziska Eckert, Aniello Federico, Sibylle Madlener, Natalia Stepien, Bernhard Robl, Alicia Baumgartner, Johannes A Hainfellner, Karin Dieckmann, Christian Dorfer, Karl Roessler, Nina S Corsini, Klaus Holzmann, Wolfgang M Schmidt, Andreas Peyrl, Amedeo A Azizi, Christine Haberler, Alexander Beck, Stefan M Pfister, Julia Schueler, Daniela Loetsch-Gojo, Jürgen A Knoblich, Walter Berger, Johannes Gojo
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JAK-STAT1 as therapeutic target for EGFR deficiency-associated inflammation and scarring alopecia
Karoline Strobl, Jörg Klufa, Regina Jin, Lena Artner-Gent, Dana Krauß, Philipp Novoszel, Johanna Strobl, Georg Stary, Igor Vujic, Johannes Griss, Martin Holcmann, Matthias Farlik, Bernhard Homey, Maria Sibilia and Thomas Bauer
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Breast cancer secretes anti-ferroptotic MUFAs and depends on selenoprotein synthesis for metastasis
Tobias Ackermann, Engy Shokry, Ruhi Deshmukh, Jayanthi Anand, Laura C A Galbraith, Louise Mitchell, Giovanny Rodriguez-Blanco, Victor H Villar, Britt Amber Sterken, Colin Nixon, Sara Zanivan, Karen Blyth, David Sumpton, Saverio Tardito
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Telomere transcripts act as tumor suppressor and are associated with favorable prognosis in colorectal cancer with low proliferating cell nuclear antigen expression
Kienzl P, Deloria AJ, Hunjadi M, Hadolt JM, Haering MF, Bothien A, Mejri D, Korkut-Demirbaş M, Sampl S, Weber G, Pirker C, Laengle S, Braunschmid T, Dragona E, Marian B, Gagos S, Lu L, Henson JD, Lau LMS, Reddel RR, Mikulits W, Stättner S, Holzmann K.
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Systemic antibody responses against gut microbiota flagellins implicate shared and divergent immune reactivity in Crohn’s disease and chronic fatigue syndrome
Bourgonje A.R., Hörstke N.V., Fehringer M., Innocenti G., Vogl T.#
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The temporal progression of lung immune remodeling during breast cancer metastasis
Christopher S. McGinnis, Zhuang Miao, Daphne Superville, Winnie Yao, Andrei Goga, Nathan E. Reticker-Flynn, Juliane Winkler & Ansuman T. Satpathy
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The histone deacetylase HDAC1 controls dendritic cell development and anti-tumor immunity
Cristiano De Sá Fernandes, Philipp Novoszel, Tommaso Gastaldi, Dana Krauß, Magdalena Lang, Ramona Rica, Ana P. Kutschat, Martin Holcmann, Wilfried Ellmeier, Davide Seruggia, Herbert Strobl, Maria Sibilia
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Evaluation of the "Burgenland PREvention trial of colorectal cancer Disease with ImmunologiCal Testing" (B-PREDICT)-a population-based colorectal cancer screening program
Stefanie Brezina #, Gernot Leeb #, Andreas Baierl, Evelyn Gräf, Monika Hackl, Philipp Hofer, Harald Lang, Michaela Klein, Karl Mach, Remy Schwarzer, Wilhelm Wlassits, Andreas Püspök #, Andrea Gsur #
# Contributed equally
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# Contributed equally
Targeting YB-1 via entinostat enhances cisplatin sensitivity of pleural mesothelioma in vitro and in vivo
Schelch K, Emminger D, Zitta B, Johnson TG, Kopatz V, Eder S, Ries A, Stefanelli A, Heffeter P, Hoda MA, Hoetzenecker K, Dome B, Berger W, Reid G, Grusch M.
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Effective targeting of breast cancer by the inhibition of P-glycoprotein mediated removal of toxic lipid peroxidation byproducts from drug tolerant persister cells
Kornélia Szebényi, András Füredi, Eszter Bajtai, Sai Nagender Sama, Agnes Csiszar, Balázs Gombos, Pál Szabó, Michael Grusch, Gergely Szakács
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Degradable Bottlebrush Polypeptides and the Impact of their Architecture on Cell Uptake, Pharmacokinetics, and Biodistribution In Vivo
Paul Strasser, Bianca Montsch, Silvia Weiss, Haider Sami, Christoph Kugler, Sonja Hager, Hemma Schueffl, Robert Mader, Oliver Brüggemann, Christian R Kowol, Manfred Ogris , Petra Heffeter, Ian Teasdale
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Mesothelioma‑associated fibroblasts enhance proliferation and migration of pleural mesothelioma cells via c‑Met/PI3K and WNT signaling but do not protect against cisplatin
Alexander Ries, Daniela Flehberger, Astrid Slany, Christine Pirker, Johanna C. Mader, Thomas Mohr, Karin Schelch, Katharina Sinn, Berta Mosleh, Mir Alireza Hoda, Balazs Dome, Helmut Dolznig, Georg Krupitza, Leonhard Müllauer, Christopher Gerner, Walter Berger & Michael Grusch
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Molecular and Pharmacological Bladder Cancer Therapy Screening: Discovery of Clofarabine as a Highly Active Compound
Ertl IE, Lemberger U, Ilijazi D, Hassler MR, Bruchbacher A, Brettner R, Kronabitter H, Gutmann M, Vician P, Zeitler G, Koren A, Lardeau CH, Mohr T, Haitel A, Compérat E, Oszwald A, Wasinger G, Clozel T, Elemento O, Kubicek S, Berger W, Shariat SF.
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The Anticancer Ruthenium Compound BOLD-100 Targets Glycolysis and Generates a Metabolic Vulnerability towards Glucose Deprivation
Baier D, Schoenhacker-Alte B, Rusz M, Pirker C, Mohr T, Mendrina T, Kirchhofer D, Meier-Menches SM, Hohenwallner K, Schaier M, Rampler E, Koellensperger G, Heffeter P, Keppler B, Berger W.
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In-depth proteomic analysis reveals unique subtype-specific signatures in human small-cell lung cancer
Beáta Szeitz, Zsolt Megyesfalvi, Nicole Woldmar, Zsuzsanna Valkó, Anna Schwendenwein, Nándor Bárány, Sándor Paku, Viktória László, Helga Kiss, Edina Bugyik, Christian Lang, Attila Marcell Szász, Luciana Pizzatti, Krisztina Bogos, Mir Alireza Hoda, Konrad Hoetzenecker, György Marko-Varga, Peter Horvatovich, Balázs Döme, Karin Schelch, Melinda Rezeli
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The AP-1 transcription factors c-Jun and JunB are essential for CD8α conventional dendritic cell identity
Novoszel P, Drobits B, Holcmann M, Fernandes CS, Tschismarov R, Derdak S, Decker T, Wagner EF, Sibilia M.
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