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Grasl-Kraupp Lab

  1. Center for Cancer Research
  2. Research Focuses
  3. Chemical Safety and Cancer Prevention
  4. Bettina Grasl-Kraupp

Bettina Grasl-Kraupp, Ao.Univ.-Prof.in Dr.in

EUROPEAN Registered Toxicologist

Research Focus

Hepatocellular carcinoma is among the most frequent causes of cancer death worldwide. The incidence in Austria and other European countries is increasing and the prognosis is poor. Therefore, knowledge-based advances in prevention and therapy of this life-threatening disease are of utmost importance

Chemical compounds, including food components or contaminants in the food chain, are among the most important causes of human cancer. The focus of our research group is a profound mechanistic understanding of chemical hepatocarcinogenesis and the single steps of this complex process.

Selected Publications

Systemic PFOS and PFOA exposure and disturbed lipid homeostasis in humans: what do we know and what not?
Fragki S, Dirven H, Fletcher T, Grasl-Kraupp B, Bjerve Gützkow K, Hoogenboom R, Kersten S, Lindeman B, Louisse J, Peijnenburg A, Piersma AH, Princen HMG, Uhl M, Westerhout J, Zeilmaker MJ, Luijten M.
Crit Rev Toxicol. 2021 Feb;51(2):141-164. doi: 10.1080/10408444.2021.1888073

Interaction of FGF9 with FGFR3-IIIb/IIIc, a putative driver of growth and aggressive behaviour of hepatocellular carcinoma
Paur J, Valler M, Sienel R, Taxauer K, Holzmann K, Marian B, Unterberger A, Mohr T, Berger W, Gvozdenovich A, Schimming J, Grusch M, Grasl-Kraupp B.
Liver Int. 2020 Sep;40(9):2279-2290. doi: 10.1111/liv.14505

Risk assessment of aflatoxins in food
EFSA Panel on Contaminants in the Food Chain (CONTAM)
Schrenk D, Bignami M, Bodin L, Chipman JK, Del Mazo J, Grasl-Kraupp B, Hogstrand C, Hoogenboom LR, Leblanc JC, Nebbia CS, Nielsen E, Ntzani E, Petersen A, Sand S, Schwerdtle T, Vleminckx C, Marko D, Oswald IP, Piersma A, Routledge M, Schlatter J, Baert K, Gergelova P, Wallace H.
EFSA J. 2020 Mar 9;18(3):e06040. doi: 10.2903/j.efsa.2020.6040

Analysis of Liver Cancer Cell Lines Identifies Agents With Likely Efficacy Against Hepatocellular Carcinoma and Markers of Response
Caruso S, Calatayud AL, Pilet J, La Bella T, Rekik S, Imbeaud S, Letouzé E, Meunier L, Bayard Q, Rohr-Udilova N, Péneau C, Grasl-Kraupp B, de Koning L, Ouine B, Bioulac-Sage P, Couchy G, Calderaro J, Nault JC, Zucman-Rossi J, Rebouissou S.
Gastroenterology. 2019 Sep;157(3):760-776. doi: 10.1053/j.gastro.2019.05.001

Risk assessment of nitrate and nitrite in feed
EFSA Panel on Contaminants in the Food Chain (CONTAM)
Schrenk D, Bignami M, Bodin L, Chipman JK, Del Mazo J, Grasl-Kraupp B, Hoogenboom LR, Leblanc JC, Nebbia CS, Nielsen E, Ntzani E, Petersen A, Sand S, Schwerdtle T, Vleminckx C, Wallace H, Bampidis V, Cottrill B, Frutos MJ, Furst P, Parker A, Binaglia M, Christodoulidou A, Gergelova P, Guajardo IM, Wenger C, Hogstrand C.
EFSA J. 2020 Nov 4;18(11):e06290. doi: 10.2903/j.efsa.2020.6290

Mesenchyme-derived growth factors enhance preneoplastic growth by non-genotoxic carcinogens in rat liver
Nejabat M, Riegler T, Reitinger T, Subosits S, Römer M, Eichner J, Bilban M, Zell A, Huber WW, Schulte-Hermann R, Grasl-Kraupp B.
Arch Toxicol. 2018 Feb;92(2):953-966. doi: 10.1007/s00204-017-2080-0

Risk to human health related to the presence of perfluorooctane sulfonic acid and perfluorooctanoic acid in food
EFSA Panel on Contaminants in the Food Chain (CONTAM)
Knutsen HK, Alexander J, Barregård L, Bignami M, Brüschweiler B, Ceccatelli S, Cottrill B, Dinovi M, Edler L, Grasl-Kraupp B, Hogstrand C, Hoogenboom LR, Nebbia CS, Oswald IP, Petersen A, Rose M, Roudot AC, Vleminckx C, Vollmer G, Wallace H, Bodin L, Cravedi JP, Halldorsson TI, Haug LS, Johansson N, van Loveren H, Gergelova P, Mackay K, Levorato S, van Manen M, Schwerdtle T.
EFSA J. 2018 Dec 13;16(12):e05194. doi: 10.2903/j.efsa.2018.5194. eCollection 2018 Dec.

Proliferation markers are associated with MET expression in hepatocellular carcinoma and predict tivantinib sensitivity in vitro
Rebouissou S, La Bella T, Rekik S, Imbeaud S, Calatayud AL, Rohr-Udilova N, Martin Y, Couchy G, Bioulac-Sage P, Grasl-Kraupp B, de Koning L, Ganne-Carrie N, Nault JC, Ziol M, Zucman-Rossi J.
Clin Cancer Res. 2017 Aug 1;23(15):4364-4375. doi: 10.1158/1078-0432.CCR-16-3118. .

Fibroblast growth factor receptor 3 isoforms: Novel therapeutic targets for hepatocellular carcinoma?
Paur J, Nika L, Maier C, Moscu-Gregor A, Kostka J, Huber D, Mohr T, Heffeter P, Schrottmaier WC, Kappel S, Kandioler D, Holzmann K, Marian B, Berger W, Grusch M, Grasl-Kraupp B.
Hepatology. 2015 Dec;62(6):1767-78. doi: 10.1002/hep.28023.

Proinflammatory mesenchymal effects of the non-genotoxic hepatocarcinogen phenobarbital: a novel mechanism of antiapoptosis and tumor promotion
Riegler T, Nejabat M, Eichner J, Stiebellehner M, Subosits S, Bilban M, Zell A, Huber WW, Schulte-Hermann R, Grasl-Kraupp B.
Carcinogenesis. 2015 Dec;36(12):1521-30. doi: 10.1093/carcin/bgv135.

All Publications

PubMedDataBase

Presentation Bettina Grasl-Kraupp, Siegfried Knasmüller

Data protection

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