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Tardito Lab

  1. Center for Cancer Research
  2. Research Focuses
  3. Cellular and Molecular Tumor Biology
  4. Saverio Tardito

Saverio Tardito, Ass.-Prof. Dr.

Research Focus

Oncometabolism Lab

Oncometabolism

The influence of metabolism on cancer initiation, progression, and response to therapy has never been more evident. The global rise in lifestyle-related metabolic conditions like obesity, diabetes, and metabolic syndrome is not only increasing cancer incidence but also compromising cancer survivorship.

Recent research, including that of Tardito’s group, shows that metabolic dysfunction plays a crucial role in how tumours form, grow, and respond to treatment. The metabolism of cancer cells is reprogrammed by their genetic and epigenetic alterations, tissue-specific microenvironment, and by the interaction with systemic metabolism. The clinical implications of this complex interplay, known as Oncometabolism, highlight the need to deepen our understanding of these metabolic connections to develop more effective approaches for cancer prevention and treatment.

Selected Publications

Breast cancer secretes anti-ferroptotic MUFAs and depends on selenoprotein synthesis for metastasis
Ackermann T, Shokry E, Anand J, Galbraith LCA, Mitchell L, Rodriguez-Blanco G, Villar VH, Sterken BA, Nixon C, Zanivan S, Blyth K, Sumpton D, Tardito S.
EMBO Mol Med 2024 (accepted for publication).

Hepatic glutamine synthetase controls N5-methylglutamine in homeostasis and cancer
Villar VH, Allega MF, Deshmukh R, Ackermann T, Nakasone MA, Vande Voorde J, Drake TM, Oetjen J, Bloom A, Nixon C, Müller M, May S, Tan EH, Vereecke L, Jans M, Blancke G, Murphy DJ, Huang DT, Lewis DY, Bird TG, Sansom OJ, Blyth K, Sumpton D, Tardito S.
Nat Chem Biol. 2023 Mar;19(3):292-300. doi: 10.1038/s41589-022-01154-9.
Issue Cover

Mesenchymal stromal cells cultured in physiological conditions sustain citrate secretion with glutamate anaplerosis
Taurino G, Deshmukh R, Villar VH, Chiu M, Shaw R, Hedley A, Shokry E, Sumpton D, Dander E, D'Amico G, Bussolati O, Tardito S.
Mol Metab. 2022 Sep;63:101532. doi: 10.1016/j.molmet.2022.101532. Epub 2022 Jun 22.

Improving the metabolic fidelity of cancer models with a physiological cell culture medium
Vande Voorde J, Ackermann T, Pfetzer N, Sumpton D, Mackay G, Kalna G, Nixon C, Blyth K, Gottlieb E, Tardito S.
Sci Adv. 2019 Jan 2;5(1):eaau7314. doi: 10.1126/sciadv.aau7314. eCollection 2019 Jan.

It doesn’t matter how smart you are
Tardito S.
Trends in Mol Med 2021 Volume 27 Issue 11, p1017-1084, e1-e2

Interested in joining the Oncometabolism Lab?

We are seeking passionate and curious researchers at all career levels (MSc, PhD, Postdoc). If you are inspired to understand the role of metabolism in tumour initiation progression and response to therapy, we want to hear from you!

For informal inquiries, please send an email to Saverio with your CV, a cover letter (max two pages) explaining your interest in our research, which specific project you would like to develop, and how you envision contributing to our work. Please also indicate the contact information of two referees who can speak to your qualifications and character.

 Mail to Saverio Tardito

Plasmax cell culture medium

For Plasmax™ medium click on the bottle