Skip to main content Deutsch

Heidenreich Lab

Erich Heidenreich, Ao.Univ.-Prof. Dr.

Research Focus

Mutation research is an important field of cancer research since cancer is a genetic disease of somatic cells. Our research focuses on spontaneous and induced mutagenic processes especially in non-proliferating or slowly proliferating cells. Utilizing the simple eukaryotic model organism Saccharomyces cerevisiae, we investigate the interrelation of spontaneous DNA damage and the action and regulation of different DNA repair pathways and try to elucidate the actual mutation-generating processes.

Selected Publications

The relevance of oxidative stress and cytotoxic DNA lesions for spontaneous mutagenesis in non-replicating yeast cells
Steinboeck F, Hubmann M, Bogusch A, Dorninger P, Lengheimer T, Heidenreich E.;
Mutat Res. 2010 Jun 1;688(1-2):47-52. doi: 10.1016/j.mrfmmm.2010.03.006.

A mutation-promotive role of nucleotide excision repair in cell cycle-arrested cell populations following UV irradiation
Heidenreich E, Eisler H, Lengheimer T, Dorninger P, Steinboeck F.;
DNA Repair (Amst). 2010 Jan 2;9(1):96-100. doi: 10.1016/j.dnarep.2009.10.007

Adaptive mutation in Saccharomyces cerevisiae
Heidenreich E.;
Crit Rev Biochem Mol Biol. 2007 Jul-Aug;42(4):285-311.

Non-homologous end joining as an important mutagenic process in cell cycle-arrested cells
Heidenreich E, Novotny R, Kneidinger B, Holzmann V, Wintersberger U.
EMBO J. 2003 May 1;22(9):2274-83.

All Publications

PubMed Database